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Fasting glucose readings should be used to titrate basal insulin, whereas both preprandial and postprandial glucose readings should be used to titrate mealtime insulin.
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But for many women a substantial increase in both short-acting and long-acting insulins during the few days prior to their period improves premenstrual symptoms and blood sugar control.
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As a result, the insulin levels, even when the blood sugar level is normal, are much higher than they are in healthy persons.
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Receiving too much basal insulin, or receiving it at the wrong times, can result in frequent (and perhaps severe) hypoglycemia as well as unwanted weight gain.
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Because the side effects can be more dangerous than the diabetes itself, pancreas transplants are generally reserved for those with very difficult-to-manage diabetes, or for people who also need a kidney transplant.
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Consumption of a meal stimulates insulin secretion from the pancreatic β-cells and activates a cascade of events as mentioned above that culminate in the movement of the GLUT4 vesicle to the plasma membrane thus increasing transport of glucose from the blood into the cell to participate in metabolism or storage as glycogen.
Nestler from the University of Virginia has spent the last eight years doing multiple studies to show that DHEA levels are directly correlated with insulin levels, or I should say insulin resistance.
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Besides having a predisposition to diabetes, insulin-resistant people may have other health issues, too, including high blood pressure, high cholesterol, heart disease, and polycystic ovarian syndrome (PCOS), a leading cause of infertility issues.
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